In this review, we will outline a diagnostic approach to jaundice, beginning with pathophysiology of cholestasis followed by hyperbilirubinemia and markers of synthetic dysfunction. Jaundice - A Review J Review Article . Res., 44(2), May - June 2017; Article No. This article was prepared at the invitation of the Clinical Sciences Reviews Committee of the Association for Clinical Biochemistry. Jaundice Related Journals Jaundice in the newborn Last revised in November 2015 Next planned review by December 2021. Neonatal jaundice caused in new-borns is common and not fatal. In the present study, we aimed to assess systematically available evidence on causes and management of jaundice in Iranian newborn patients.
Jaundice is also referred to as icterus, the yellow staining of the skin and the whites of the eyes by abnormally high blood levels of the bile pigment, bilirubin. Rev.
Jaundice is a sign of an underlying disease process. M. Jeffrey Maisels, MB, BCh* 1. A healthy newborn may acquire jaundice because the liver has not fully matured.
2. Jaundice in Infants. We searched the databases of PubMed, Web of Sciences, Scopus and Google Scholar for English articles published since inception until May 2019. Patient with 50 years - old with painless jaundice ( 13,5 ng/dl) , she presented a stopping at hepatic hylum diagnosed by both CT and Colangioresonance ( she was classified as Type 2 … A search was also done for Persian articles in … Neonatal jaundice first becomes visible in the face and forehead. Jaundice, or icterus, is yellowish discoloration of the skin, mucous membranes, sclerae, and body fluids resulting from excess accumulation and deposition of bilirubin in the body in the presence of serum hyperbilirubinemia. Understand the metabolism of bilirubin. English language literature was reviewed using MEDLINE, PubMed, EMBASE and clinicaltrials.gov for papers and trails addressing the pathophysiology and potential treatments for pruritis associated with jaundice. Jaundice then gradually becomes visible on the trunk and extremities. 2. Some of the symptoms of jaundice include yellowing of the whites of the eyes or skin, rectal bleeding, dark urine, nausea, vomiting, weakness, weight loss, headache, and abdominal pain. Sci. The yellow hue may be mimicked by carotenemia, but in the latter condition, no scleral icterus is present and bilirubin levels are normal. J. Pharm. Jaundice or hyperbilirubinemia in adults is caused by an underlying disease or condition. More intense jaundice … Describe the factors that place an infant at risk for developing severe hyperbilirubinemia. In adults, it is caused by accumulation of bilirubin in blood and tissues. After completing this article, readers should be able to: List the risk factors for severe hyperbilirubinemia. Midland Diagnostic Lab, Belgharia, Kolkata, West Bengal, India. Back to top Jaundice in the newborn: Summary Jaundice is a yellow colouration of the skin and sclerae (whites of the eyes) caused by the accumulation of bilirubin, a bile pigment which is mainly produced from the breakdown of red blood cells. *Department of Pediatrics, William Beaumont Hospital, Royal Oak, Mich After reviewing this article, readers should be able to: 1.
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