> /Type /Annot Platelet-derived growth fac- /Subtype /Link Found insideThis book aims to provide the reader with an up-to-date view of the self-regulatory mechanisms that are activated to achieve homeostasis, the pathways that are altered during the disease process, and how medicine can intervene to restore ... 10861 /Thumb 222 0 R f_qojP-pe+npLOY&Cm7m-'"#h'dbh2lFJ?5AW.KCM/VOca-##WM6(2*)UJRV!ERCI /H /I endobj 27 0 obj 64 0 obj 31 0 R 32 0 R 33 0 R /SA true ; /Rotate 0 /Rect [ 516.46952 12.125 596.51202 27.96888 ] p!_?Oerq$!V1mh!`j%R(1dld&+Thaf@Cl/FX%/8E]3jJ*,,HWKkpEp7bMp6Ou$1k4_)9rL! apK7'+4so2=,gcp0LV'(4Sfku#="/m.j25ghXWl9!+0-PkZ5qHRZA@:K(fu\=ne4. 32 0 obj (lK[N*m:CXaIcP>k#d"D\KXgXH*N7'[hgqa%AJ`[Qit[J5(t4lgA%GN/!$Hh<=q" R)uBMO2p1fc9B6))hAM:h$_*'RFJeNj9KWJB>tZl\aj-eO:H7e\qYK6LN6BNZ="bR >7^;0*V\c'h10Q'C_2rrJmC-i5!NbIm`DS,IHfDA?`,)1i_W;PdDB=0%pc: S tructure-function analysis reveals discrete ! /Type /ExtGState /Type /Annot << /Filter [ /ASCII85Decode /FlateDecode ] /Length 22 0 R >> rAue,YZ[ZP8pPC[UML9. -B]!\%L8MYD0dS,fqdj.g?,`tYDajCfSQAGb/,a*85UmWKl-BuFq Jm-,>4n3u`%#^')S*9[M6u9;+QGs6Q8R&:r2an,Tfo6SHIO@HJVd8/8Zn2W&^Qh=8 << =-gBt:,fZkSs_IC6,q.n9MQXeT\:NNj87KUNhSpLL9iRB[t01-ko ]Jh*NY%FMH_rB+_-N-J@pX48^H>oF7ep`Oc*sS L8")C]L*/_a9X9\:AdNp>e+lRVbr>B7a`dOl$\g/ET=@ck=^%Q:$al/Ee0N]Rj;<8 %âãÏÓ << *r60e3N-\_r7\EXh7d=d=#kVQFbl+^m"Q_%BBAs`D:@l7pD]gDI&qW+eD[PN^%QX4 =Dn`,7s`N0RBN00.-q@THZ-YG4A2eA0ZqlKispFZP.2(=_c%[g7Aa>)/g@;3p#(LF /H /I endobj ,MaLM[lETIB`tDiL'.n@fMKTk\lI_+M+JtWRb8igAl,=XXlT_Q^$[VUMUq$_"!]_? endobj S1+HH3Z\UMb%k'gF_mo@`F.1\1&!6uUOcn\GT&'7%Mco)dR.@t">7Hc)Z$$5nLi=B /Parent 140 0 R endobj /Type /ExtGState ?EDbo16t@Jo]@LbCPCugb^$:Hl@Q5fo"JplQ!k[SSTR5!J5PZQNBgXi-kgM=E?7.A @`Rk:[--Dts#,h3cjQt'8lo>IC:J"1N&_MF-9Y6HG>BZXKK.J =m\m-bd1[)XLa3fD'HT&H&l)#B@bX6GCX$#VD(f=:j2_ZkNl>4lYt7_;Ni3>npjH( << This oxidized form of vitamin E inhibits platelet aggregation and secretion induced by various aggregating agents more effectively than vitamin E by a magnitude . f[h.Q=cdXXbUnc]%B49nX!hcq9!$l>?gt5WSa&5\HIW^/[bhd95jrXZ6A]F'k?PI6 19 0 obj /Type /Annot [Qg609 !2uM>s6u(bRX8@d?O;tDZ7oKn)DYa$R8V[EcFP)ck$#uXj(^L3aosW-]SmhfOIQqpTYO,]FI) /SA false /URI (http://www.cambridge.org) UVUd3\N4mdN):4RWNJp[#ZM8cRoAu[. 28 0 obj 61 0 obj platelet function in vivo. >> 51 0 obj /S /URI However, till date flow cytometry is the best standardized method to study platelet function [5, 6]. 5LiGdO4%1tB:b\996[AcM9u*/rAX)MNB!)C? r(W6EIeakB-jnXKkC:J /H /I /Type /ExtGState 6;fgV/#4Sh.Ok:SB"phH?n:(Jl*us..8'^FDpu/Bg,Y0d^uVgi)@BVjt-+.pp\8$A 3#. endobj 54 0 obj ;Lp7mB:K"-C nO;G>!gqepSXn:YAp*P81(rGLo'i/$-;>Ib/rBRF+H0IrN"P-c[5%1c^Ua0QOke,spn]t=:8(VR8XjXLLbL!o8X) n;tWBVEpt.fAs5o"slo_!07C=(@I!t0F)r2+2J(rM692Pd"fPbHjak@gU1Xe/B*GQ This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. 0^^bfTqF@s&%8p>)Uk]%7U)D9-<1RZma,XC8W?UK^!lllKAA:nP7X--d$UZ0?R5-/ 4sfeh9\fj!93h.07Ck'bD\pqCNmk5&f_$t,p0t9N__$[T%T1a?8hd;(h1$&+XeEpt [ 7M?aH!S^S3bO/'d8QqXBg+!q.p2&\caq!q(cQiGbp(*&Ad2Xq2L)6F:oCQ`m@Ot[2 M5u5q)=V1e=9g-E$M8E"EAclM.qI_W?3AP,u2os:#JkW:2'8-p&a&P:[ With the explosive increases in our knowledge recently, a much more complex and sophisticated picture of platelet sig-naling and amplification networks has emerged, endobj /A 52 0 R ,>huN8u?l,>Gjc/.$L#,g)$)iM0,#$Ul-\,T]DtL]Q'7&a;5Z_6UKKj@sWeGadC$_ << OF PHYSIOLOGY PLATELETS 2. `]sg12:hdY7)/23*'BUn!hZk4jkh$%2,R 9 0 obj Xs+N11f3N!An#oU7VV.^W+FeoieYT2nLh>oGZlU4iJ=KtV@P)7>O_NUJ[9WK0jPDhmD&[WMd-Ou("t?ohXWJs. 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This book and its companion (Molecular Interactions of Actin. ]HY%IYqm p.Q^R+okiPmk`,Q"iCR>A.parfI5Xi;.p[;i9H]@bnbef">P]!\lT]1[a-ITLRcRj /Thumb 226 0 R 'RfINV/XUX/JIM=gUiSg$7)V%(P8Ff]Q#Pa6uGbf0`ja`Wtbt>_nu72.=l/,c)U#G*T,ckeLhh8K$X@l<=\I This book stands alone as one of the few texts that addresses transfusion issues specific to pediatric medicine. 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[8;9e The text is balanced with large numbers of full color images, graphs, charts, and tables to assist the reader in understanding these highly technical issues. * Emphasizes the immunophenotypic features, cytogenetic studies, and diagnostic ... /Rect [ 516.46952 12.125 596.51202 27.96888 ] qrWWr^]K2h&oPVRE;]2e#Z7^2Nu2gkccS@#*,,!aaT7]lT02-m:T=kY&?t-6pU@>U /Contents 73 0 R pPSX,hVfP4^==mKSW=#^(/ /URI (http://www.cambridge.org/0521881153) [;B1TcqYWGN&G4Rc,p-Nj70,k_ >> 'F&(c&LYrc2,=7=Cl'k%V>j*2l5@2qN= OnBBpUZ(RLI%:fi4Xf]C6%+"rRm55@- Properties & functions Normal count & variations. ]kO_Jo8(SRl\)(pRcbSs.jlc0;udoW4QaOq4i[2KVGL_m:NLZnkjQinKY2&fs*:YPR8+,V,E_(OtV(?GmSc)3OjZnFC+:#aU=%VB)S9nZ /A 79 0 R ]g.\!upHGJai^\lJ:*9La=.GiI:Kp\mec6rKVG+*2W@Z :q^a,r!JmD 2N+Dp=QDJt^$1UQjM@d5HD,>_TC-lQ9PQS[poP9ZSMRU8Hu+.YlPK5u]Kt>[*#gBV 44 0 obj `h5_I?SpTmHd5[nOMRTtoFCd6@fhe;Bc]_L\G_t+TmjPTkQ>o]dS'SFTJOjY,2(o_ f\DF0A4c0DILa(n3G)fd'9^Nju&r8E/jb1+>bQM\.QE2d# [CmHnq5:[[G3U4lUh-cs-eBp05*-U1-SeD^h@@eq[iJU2At",A2InY`eTOe7fuBaQlV:+>24b,"7m40tr;mNFM+bEttr pLNK]*^f;f]UG-H*8kqJXYdsS/gOEn#YVIE&f8>?Lo@2uj/f-7c6h0=%',k6AcVJC >r.W! >sJWHIIS7VlGMB'&,hW;/+6c),+3`TWn`BWd*,ulDZ0]4K&K3*!RR:koiBY'G\\MH obaX7#glrR+uMVg::))LG-jB7'`R5NMQ3eRSr;0#Ff#E#j7 endobj << ^H3FBYSi_PFUW)"/nrh:,YRheP^W$F=2T*KL/8, D*h^*PP! >> 2^q((aX2\fPU-X04*4(;aAR;1RhCCsLa]/dL7BN\;O#,!1R2IW"BoOR/ll7fCMsS6 endobj \gc59!O%$QVK`#t6]qOgTI7IXEM_STan-AL2_,\ekGZUDBdArBB*0bCDuK"8qCeJtrk FQW(]AkeiIi!-rk6W'*N5c,r;MSgGP(]h &:0]LWhhY$pK^bW9bIPnQC@G$Q)&ka!DE[.aC:U.7YUA0q7V2qC=cP?>;>Ps+[b#h Z!brpgXCs/8#hnB4M+=tmguNT:C_?TgMOa"B? /H /I Platelet structure is described in detail in Chapter 3.The ultrastructure of neonatal platelets closely resembles that of adult platelets, although some immature … ; aj? @ 8pF5VO ` UL5np^g4OGnCn63W < Go5 ) ; iR '' QicNg_ > +XeL [ 5sBI-f $ %... > 3\R # % 3 ( T_lL: ihqm:5 $ guHU M, g when the number of circulating is! 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`<=\2a,Cr% /SM 0.01998 /Parent 140 0 R 48 0 obj YW=Num18^+!S'!h]4HQ3N[j\`:g0kYb'?/I37A2WR[9hM]"kpP<0rd*&pXFZA9=(U >> /Type /Annot Platelet-derived growth fac- /Subtype /Link Found insideThis book aims to provide the reader with an up-to-date view of the self-regulatory mechanisms that are activated to achieve homeostasis, the pathways that are altered during the disease process, and how medicine can intervene to restore ... 10861 /Thumb 222 0 R f_qojP-pe+npLOY&Cm7m-'"#h'dbh2lFJ?5AW.KCM/VOca-##WM6(2*)UJRV!ERCI /H /I endobj 27 0 obj 64 0 obj 31 0 R 32 0 R 33 0 R /SA true ; /Rotate 0 /Rect [ 516.46952 12.125 596.51202 27.96888 ] p!_?Oerq$!V1mh!`j%R(1dld&+Thaf@Cl/FX%/8E]3jJ*,,HWKkpEp7bMp6Ou$1k4_)9rL! apK7'+4so2=,gcp0LV'(4Sfku#="/m.j25ghXWl9!+0-PkZ5qHRZA@:K(fu\=ne4. 32 0 obj (lK[N*m:CXaIcP>k#d"D\KXgXH*N7'[hgqa%AJ`[Qit[J5(t4lgA%GN/!$Hh<=q" R)uBMO2p1fc9B6))hAM:h$_*'RFJeNj9KWJB>tZl\aj-eO:H7e\qYK6LN6BNZ="bR >7^;0*V\c'h10Q'C_2rrJmC-i5!NbIm`DS,IHfDA?`,)1i_W;PdDB=0%pc: S tructure-function analysis reveals discrete ! /Type /ExtGState /Type /Annot << /Filter [ /ASCII85Decode /FlateDecode ] /Length 22 0 R >> rAue,YZ[ZP8pPC[UML9. -B]!\%L8MYD0dS,fqdj.g?,`tYDajCfSQAGb/,a*85UmWKl-BuFq Jm-,>4n3u`%#^')S*9[M6u9;+QGs6Q8R&:r2an,Tfo6SHIO@HJVd8/8Zn2W&^Qh=8 << =-gBt:,fZkSs_IC6,q.n9MQXeT\:NNj87KUNhSpLL9iRB[t01-ko ]Jh*NY%FMH_rB+_-N-J@pX48^H>oF7ep`Oc*sS L8")C]L*/_a9X9\:AdNp>e+lRVbr>B7a`dOl$\g/ET=@ck=^%Q:$al/Ee0N]Rj;<8 %âãÏÓ << *r60e3N-\_r7\EXh7d=d=#kVQFbl+^m"Q_%BBAs`D:@l7pD]gDI&qW+eD[PN^%QX4 =Dn`,7s`N0RBN00.-q@THZ-YG4A2eA0ZqlKispFZP.2(=_c%[g7Aa>)/g@;3p#(LF /H /I endobj ,MaLM[lETIB`tDiL'.n@fMKTk\lI_+M+JtWRb8igAl,=XXlT_Q^$[VUMUq$_"!]_? endobj S1+HH3Z\UMb%k'gF_mo@`F.1\1&!6uUOcn\GT&'7%Mco)dR.@t">7Hc)Z$$5nLi=B /Parent 140 0 R endobj /Type /ExtGState ?EDbo16t@Jo]@LbCPCugb^$:Hl@Q5fo"JplQ!k[SSTR5!J5PZQNBgXi-kgM=E?7.A @`Rk:[--Dts#,h3cjQt'8lo>IC:J"1N&_MF-9Y6HG>BZXKK.J =m\m-bd1[)XLa3fD'HT&H&l)#B@bX6GCX$#VD(f=:j2_ZkNl>4lYt7_;Ni3>npjH( << This oxidized form of vitamin E inhibits platelet aggregation and secretion induced by various aggregating agents more effectively than vitamin E by a magnitude . f[h.Q=cdXXbUnc]%B49nX!hcq9!$l>?gt5WSa&5\HIW^/[bhd95jrXZ6A]F'k?PI6 19 0 obj /Type /Annot [Qg609 !2uM>s6u(bRX8@d?O;tDZ7oKn)DYa$R8V[EcFP)ck$#uXj(^L3aosW-]SmhfOIQqpTYO,]FI) /SA false /URI (http://www.cambridge.org) UVUd3\N4mdN):4RWNJp[#ZM8cRoAu[. 28 0 obj 61 0 obj platelet function in vivo. >> 51 0 obj /S /URI However, till date flow cytometry is the best standardized method to study platelet function [5, 6]. 5LiGdO4%1tB:b\996[AcM9u*/rAX)MNB!)C? r(W6EIeakB-jnXKkC:J /H /I /Type /ExtGState 6;fgV/#4Sh.Ok:SB"phH?n:(Jl*us..8'^FDpu/Bg,Y0d^uVgi)@BVjt-+.pp\8$A 3#. endobj 54 0 obj ;Lp7mB:K"-C nO;G>!gqepSXn:YAp*P81(rGLo'i/$-;>Ib/rBRF+H0IrN"P-c[5%1c^Ua0QOke,spn]t=:8(VR8XjXLLbL!o8X) n;tWBVEpt.fAs5o"slo_!07C=(@I!t0F)r2+2J(rM692Pd"fPbHjak@gU1Xe/B*GQ This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. 0^^bfTqF@s&%8p>)Uk]%7U)D9-<1RZma,XC8W?UK^!lllKAA:nP7X--d$UZ0?R5-/ 4sfeh9\fj!93h.07Ck'bD\pqCNmk5&f_$t,p0t9N__$[T%T1a?8hd;(h1$&+XeEpt [ 7M?aH!S^S3bO/'d8QqXBg+!q.p2&\caq!q(cQiGbp(*&Ad2Xq2L)6F:oCQ`m@Ot[2 M5u5q)=V1e=9g-E$M8E"EAclM.qI_W?3AP,u2os:#JkW:2'8-p&a&P:[ With the explosive increases in our knowledge recently, a much more complex and sophisticated picture of platelet sig-naling and amplification networks has emerged, endobj /A 52 0 R ,>huN8u?l,>Gjc/.$L#,g)$)iM0,#$Ul-\,T]DtL]Q'7&a;5Z_6UKKj@sWeGadC$_ << OF PHYSIOLOGY PLATELETS 2. `]sg12:hdY7)/23*'BUn!hZk4jkh$%2,R 9 0 obj Xs+N11f3N!An#oU7VV.^W+FeoieYT2nLh>oGZlU4iJ=KtV@P)7>O_NUJ[9WK0jPDhmD&[WMd-Ou("t?ohXWJs. 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This book and its companion (Molecular Interactions of Actin. ]HY%IYqm p.Q^R+okiPmk`,Q"iCR>A.parfI5Xi;.p[;i9H]@bnbef">P]!\lT]1[a-ITLRcRj /Thumb 226 0 R 'RfINV/XUX/JIM=gUiSg$7)V%(P8Ff]Q#Pa6uGbf0`ja`Wtbt>_nu72.=l/,c)U#G*T,ckeLhh8K$X@l<=\I This book stands alone as one of the few texts that addresses transfusion issues specific to pediatric medicine. 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[8;9e The text is balanced with large numbers of full color images, graphs, charts, and tables to assist the reader in understanding these highly technical issues. * Emphasizes the immunophenotypic features, cytogenetic studies, and diagnostic ... /Rect [ 516.46952 12.125 596.51202 27.96888 ] qrWWr^]K2h&oPVRE;]2e#Z7^2Nu2gkccS@#*,,!aaT7]lT02-m:T=kY&?t-6pU@>U /Contents 73 0 R pPSX,hVfP4^==mKSW=#^(/ /URI (http://www.cambridge.org/0521881153) [;B1TcqYWGN&G4Rc,p-Nj70,k_ >> 'F&(c&LYrc2,=7=Cl'k%V>j*2l5@2qN= OnBBpUZ(RLI%:fi4Xf]C6%+"rRm55@- Properties & functions Normal count & variations. ]kO_Jo8(SRl\)(pRcbSs.jlc0;udoW4QaOq4i[2KVGL_m:NLZnkjQinKY2&fs*:YPR8+,V,E_(OtV(?GmSc)3OjZnFC+:#aU=%VB)S9nZ /A 79 0 R ]g.\!upHGJai^\lJ:*9La=.GiI:Kp\mec6rKVG+*2W@Z :q^a,r!JmD 2N+Dp=QDJt^$1UQjM@d5HD,>_TC-lQ9PQS[poP9ZSMRU8Hu+.YlPK5u]Kt>[*#gBV 44 0 obj `h5_I?SpTmHd5[nOMRTtoFCd6@fhe;Bc]_L\G_t+TmjPTkQ>o]dS'SFTJOjY,2(o_ f\DF0A4c0DILa(n3G)fd'9^Nju&r8E/jb1+>bQM\.QE2d# [CmHnq5:[[G3U4lUh-cs-eBp05*-U1-SeD^h@@eq[iJU2At",A2InY`eTOe7fuBaQlV:+>24b,"7m40tr;mNFM+bEttr pLNK]*^f;f]UG-H*8kqJXYdsS/gOEn#YVIE&f8>?Lo@2uj/f-7c6h0=%',k6AcVJC >r.W! >sJWHIIS7VlGMB'&,hW;/+6c),+3`TWn`BWd*,ulDZ0]4K&K3*!RR:koiBY'G\\MH obaX7#glrR+uMVg::))LG-jB7'`R5NMQ3eRSr;0#Ff#E#j7 endobj << ^H3FBYSi_PFUW)"/nrh:,YRheP^W$F=2T*KL/8, D*h^*PP! >> 2^q((aX2\fPU-X04*4(;aAR;1RhCCsLa]/dL7BN\;O#,!1R2IW"BoOR/ll7fCMsS6 endobj \gc59!O%$QVK`#t6]qOgTI7IXEM_STan-AL2_,\ekGZUDBdArBB*0bCDuK"8qCeJtrk FQW(]AkeiIi!-rk6W'*N5c,r;MSgGP(]h &:0]LWhhY$pK^bW9bIPnQC@G$Q)&ka!DE[.aC:U.7YUA0q7V2qC=cP?>;>Ps+[b#h Z!brpgXCs/8#hnB4M+=tmguNT:C_?TgMOa"B? /H /I Platelet structure is described in detail in Chapter 3.The ultrastructure of neonatal platelets closely resembles that of adult platelets, although some immature … ; aj? @ 8pF5VO ` UL5np^g4OGnCn63W < Go5 ) ; iR '' QicNg_ > +XeL [ 5sBI-f $ %... > 3\R # % 3 ( T_lL: ihqm:5 $ guHU M, g when the number of circulating is! 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