Tippu Z 1, Larkin JM 1, Carr A 2, Turajlic S 1. nivolumab (nivo)) have improved outcomes in many cancers. Molecular characterisation underpinning the diversity observed has been qualified, where the near ubiquitous loss of the short arm of chromosome 3 precedes distinct evolutionary trajectories involving different seq... Background Zayd Tippu 1 , Lewis Au 2 , Samra Turajlic 3 Affiliations 1 Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK. CAPTURE is a prospective, longitudinal cohort study of cancer patients and healthcare workers (HCWs) integrating longitudinal immune profiling and clinical annotation. 1 Royal Marsden NHS Intratumour heterogeneity is recognised across different tumour types and has implications for therapeutic resistance. At present, clinical practice often relies upon molecular information derived from a single biopsy of a primary or metastatic tumour. Molecular characterisation underpinning the diversity observed has been qualified, where the near ubiquitous loss of the short arm of chromosome 3 precedes distinct evolutionary trajectories involving different sequences and combinations of genetic events. However their use is complicated by ICI-related diarrhoea/colitis (irD/C), a common cause of morbidity and ICI discontinuation. Neurological adverse events from immune checkpoint inhibition are increasingly recognised, especially with combination anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) and anti-programmed death receptor 1 (anti-PD-1) therapies. Comparison of medication adherence and persistence in type 2 diabetes: A systematic review and meta‐analysis, Systematic review of adherence rates by medication class in type 2 diabetes: a study protocol. This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile. 1Lavinia Spain*, 2Amit Samani, 1,2Hajir Ibraheim, 1Lewis Au, 2Zayd Tippu, 2Shuai Zhang, 2 Sophie Merrick, 2 Debra Josephs, 2 Waqas Fazal, 2 Sophie Papa, 1,2 Nick Powell, 1 Nadia Yousaf, 1 James Larkin, 1 Martin Gore, 1 Samra Turajlic. Affiliations. In cases #25 and #30, with native tumor tissues displaying a higher tumor mutational burden, a weaker correspondence between tumors and derived organoids was observed, likely ascribable to the procedures of tumor tissue sampling and organoid culture development. 2 Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK; The Francis Crick Institute, London, UK. ... By blocking PD-1 and PD-L1 activity these ICI's enhance anti-tumor T-cell activity. Here, we demonstrate representative sequencing (Rep-Seq) as a new method... A diverse range of clinical phenotypes are observed in clear-cell renal cell carcinoma (ccRCC) with resultant therapeutic implications. Indications for immune checkpoint inhibitor therapy are increasing. However, improved T-cell proliferation may also lead to irAEs [1. Alleh Jonroy. 4 authors ... Royal Marsden NHS Foundation Trust, London, UK. How we treat neurological toxicity from immune checkpoint inhibitors. A diverse range of clinical phenotypes are observed in clear-cell renal cell carcinoma (ccRCC) with resultant therapeutic implications. There is a pressing need to characterise the nature, extent and duration of immune response to SARS-CoV-2 in cancer patients and inform risk-reduction strategies and preserve cancer outcomes. Tamer Rabie. ; 2 Roche Tissue Diagnostics, 1910 E. Innovation Park Drive, Tucson, AZ 85755, USA. Roche Tissue Diagnostics. 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